Bioactivation of New Harmonic Titanium Alloy to Improve and Control Cellular Response and Differentiation

The purpose of this research article is to present the functionalization a new titanium alloy system TiNbZr, by grafting bioactive polymer (poly(sodium styrene sulfonate), PNaSS) using “grafting from” technique improve osseointegration. resulting grafted covalently bonded substrate in procedure thanks surface-induced polymerization. Colorimetric assay, Fourier-transform infrared spectra recorded attenuated total reflection mode (ATR-FTIR), Scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and water contact angle measurements (WCA) were applied characterize surfaces. In addition, effect on biological response was assessed MC3T3-E1 pre-osteoblast cells line. This study shown that rates obtained these are as good (around 4.5 μg/cm2) classical alloys. parallel, vitro carried out assess toxicity, cell viability, morphology alloys TiNbZr functionalized. Moreover, results showed superior alkaline phosphatase activity higher calcium deposition samples, implying beneficial PNaSS osteoinduction activity. Grafted improves response, particular,